Mechanism of Action

Sexual arousal itself does not occur when a man takes Sildenafil (Generic for Viagra). The drug requires you to be sexually prepared for intercourse. Its efficacy lies in the drug’s ability to affect the mechanics of male’s erection by modifying the muscular control of the blood flow.

The simplicity of the above mechanics allows for an almost unfailing operation of Sildenafil. Getting sexually stimulated for a man involves releasing nitric oxide (NO) through nerve cells in the erectile tissue of your penis.

A messenger molecule known as cGMP (guanosine monophosphate) is the main target of NO. The molecules of cGMP activated by NO make the cells of penile smooth muscles relax.

Dilated arteries make it easier for blood to fill the erection chambers of your penis and this leads to the erectile tissue being pumped to firmness. An erection, consequently, ensues from the stable blood pressure in the corpus spongiosum of your penis.

The cells of penile smooth muscles can use Sildenafil’s active components to maintain the level of cGMP in them. However, no nitric oxide will be released if you are not aroused, and your neural tissue will not help you get an erection by producing cGMP.

Just How Effective is Sildenafil?

The erectile function has been known to be greatly improved in the group of clinical study participants who take Sildenafil and similar erectile dysfunction (ED) medications as compared to the placebo group. Although approved by FDA as a totally safe and highly effective medication, the Sildenafil is not a universal solution to all clinical cases and may not act appropriately in every patient.

In cases, where a patient tries to use Sildenafil (Generic version of Viagra) in the management of the underlying causes of impotence, the drug has shown various degrees of the therapeutic benefit. The best results were achieved with chiefly psychological causes of ED.

The ability of patients to achieve a firm and satisfactory erection helped to resolve anxiety issues and significantly improved their psychological well-being.

In order to understand what exactly causes impotence in a certain individual, an array of tests should be performed. Primarily, a blood test for diabetes may prove useful to highlight the underlying ED causes when conducted along with triglyceride and cholesterol blood tests.

The levels of blood testosterone (the major sex hormone) also should be determined by way of blood examination.

How Soon Will I Feel the Effect?

When a Sildenafil tablet is consumed on an empty stomach, it normally begins acting in about 40 to 60 minutes, on average. Depending on your dosage regimen, you may prefer 25mg, 50mg or 100mg tables, which are the only dosages available.

Whether you respond to higher or lower drug doses is dictated by the physiological particulars of your body. You will very likely want to adjust your dose as soon as you have taken Sildenafil at least a couple of times.

Your doctor should monitor your dosage scheme and help you exclude dangerous drug  interactions. The appropriate dosage is also necessary to minimize the risk of adverse reactions.

The doctor will consider potential dangers of taking Sildenafil (Generic for Viagra) with other medications, age-related risks, how serious/prolonged is your case of erectile dysfunction and any previous good and bad experience you have had with ED meds.

Sildenafil performs at its peak efficacy for 4–6 hours. Meals reach in fat can significantly slow down the speed of its action. Also, be ready for a chance of unsuccessful use; Sildenafil sometimes does not work the first time a patient takes it.

The minimum limit of tries for Sildenafil is eight attempts, only then you will know whether or not you are totally incompatible and need to move to another popular ED drug Tadalafil.

What Side Effects and Unpleasant Reactions I May Expect?

Sildenafil is quite safe in terms of side effects, and even those mild and brief ones occur rarely. Most commonly, Sildenafil patients may experience headache and reddening of their face. Such nuisances as a stuffy nose, indigestion happen even less frequently; in exclusive cases, men have reported that their vision became blue-tinted.

You will not be able to take Sildenafil if you have ever had one or more of the following conditions in your medical history: heart attacks, strokes, pronounced heart palpitations, liver disorder(s), particular rare congenital eye diseases, low or abnormal blood pressure.

Yes, one of the most critical moments is that Sildenafil affects blood pressure (BP). In ordinary cases, men experience slightly lowered BP. But bear in mind that when taken with any nitrate-containing medication, Sildenafil’s impact on blood pressure comes to be significantly more distinct.

For instance, nitrates could be part of your angina treatment, prescribed by a doctor. Taking Sildenafil (affordable version of Viagra) a long side nitrates results in a strong combined effect and so you run the risk to lower your blood pressure to a near-fatal level. Avoid taking nitrates along with Sildenafil.

Discussion with a doctor is critically necessary in case if you have a heart disease. Again, a cardiac should observe extra caution to not start using Sildenafil along with the nitrate-based meds.